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Indeed, there is still a significant debate within the scientific community about the specific cut-off values that should be applied to define a low vitamin B12 status and about the definition of the best biomarker or combination of biomarkers to assess vitamin B12 status[1,12]

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Author contributions BM and MS substantial contributions to the conception of the work, BM and AK drafting the work, MS revising it critically for important intellectual content, BM, AK and MS final approval of the version to be published, BM, MS and AK agreement to be accountable for all aspects of the work